ow dose catheter directed thrombolysis for acute intermediary-high risk pulmonary embolism. - BETULA

Aarhus University Hospital0 个研究点目标入组 60 人开始时间: 2019年2月27日最近更新: 2021年11月22日

试验速览

暂无简介。

•- Age > 17 and < 81 years
•- Debut of symptoms <14 days
•- Acute symptomatic Intermediate-high risk PE (according to 2014 ESC guidelines) confirmed by CTA with the embolus located in at least one proximal lower lobe or main pulmonary artery.
•- Right-to-left ventricular dimension ratio >1.0 on contrast enhanced computed tomography or transthoracic echocardiography.
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 20
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range 40

•- Significant bleeding risk or other contraindications to catheter directed trombolysis or unfractioned heparin.*
•- Not possible to perform catheter directed trombolysis within 48 h after diagnosis
•- Known pregnancy or positive urine hCG screening test in fertile women**
•- Cardiac arrest requiring cardiopulmonary resuscitation
•- Life expectancy < 120 days
•- Altered mental status such that the patient is unable to provide informed consent
•- Chronic thromboembolic pulmonary hypertension
•- Sustained hypertension (>180 mmHg systolic and/or >105 mmHg diastolic)
•*Treated with thrombolytics for the index
•** Fertile women will be screened for pregnancy with a blood hCG screening test before inclusion if they are not on any contraceptives.

发起方

Aarhus University Hospital