NCT01330940已完成不适用
Effect of Diet Orange Soda on Urinary Lithogenicity
VA New York Harbor Healthcare System2 个研究点 分布在 1 个国家目标入组 12 人开始时间: 2009年11月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 12
- 试验地点
- 2
- 主要终点
- Change in urine citrate content
研究概览
简要总结
Beverages containing citrate may be useful in increasing urine citrate content and urine pH. Such changes in urine chemistry could help prevent kidney stones. Diet orange soda has more citrate than other similar beverages. The investigators are interested in whether diet soda will improve urine chemistry in the appropriate manner.
详细描述
The effect of orange soda compared with water in changing 24 hour urine citrate excretion in mg/day will be determined.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18-65 years old
- •able to sign consent
- •ability to reliably urinate into a vessel and measure urine volume
排除标准
- •prior history of nephrolithiasis
- •a known history of metabolic bone disease
- •hyperthyroidism
- •hyperparathyroidism or chronic kidney disease
- •current use of diuretics
- •current use of potassium citrate or other oral alkali supplementation and
- •use of calcium supplementation that could not be stopped
结局指标
主要结局
Change in urine citrate content
时间窗: 1 week
Citrate is measured in 24h urine sample and expressed as mg/day
次要结局
- Change in urine pH(One week)
研究者
David S. Goldfarb, M.D.
Chief, Nephrology
VA New York Harbor Healthcare System
研究点 (2)
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