Vitamin C administration in community acquired pneumonia (CURB-65 >1): a feasibility study for a randomised controlled trial

niversity of Otago0 个研究点目标入组 140 人开始时间: 2019年2月20日最近更新: 2019年7月15日

试验速览

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•1) Community acquired pneumonia (CAP) defined as: a new inflammatory infiltrate on chest radiograph and the presence of at least one of the following acute respiratory signs and symptoms: cough, sputum production, dyspnoea, core body temperature of 38.0°C or higher, auscultatory findings of abnormal breathing sounds or rales, leucocyte count > 104 cells/µL or < 4x104 cells/µL.
•2) Aged > 17 years;
•3) Able to provide informed consent
•4) Requiring IV antibiotic therapy;
•5) Moderate or severe pneumonia with a CURB-65 score > 1 at any time during their admission.

•1)Pneumonia is not the principal reason for admission;
•2)CURB-65 score 0-1;
•3)Pneumonia associated with bronchial obstruction, bronchiectasis, cystic fibrosis, or active tuberculosis;
•4) Cannot provide informed consent
•5)Previous hospitalisation within 2 weeks so that hospital-acquired pneumonia cannot be ruled out;
•6)Severe immunosuppression ( eg neutropenia 350 cells/µL, or HIV positive and a CD4 cell count below 350 cells/µL, receiving cancer chemotherapy, receiving prednisone > 20 mg daily or anti-rejection medication);
•7)Chronic kidney disease with a creatinine clearance <10 mls/sec), or receiving dialysis;
•8)Known or suspected G6PD deficiency.
•9)Pregnancy and breast feeding
•10)Haemachromatosis

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