Effect of Spinal or Sevoflurane Anesthesia on Neutrophil Activation After Tourniquet Induced Ischemia-reperfusion in Knee Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 主要终点
- Changes in plasmatic concentration of myeloperoxidase and elastase
研究概览
简要总结
Aim of study : Assessement of neutrophil activation during ischemia reperfusion associated with tourniquet use for total knee arthroplasty. This activation was compared in a group of patient scheduled for spinal anesthesia and for sevoflurane anesthesia
详细描述
Aim of study : Assessement of neutrophil activation during ischemia reperfusion associated with tourniquet use for total knee arthroplasty. This activation was compared in a group of patient scheduled for spinal anesthesia and for sevoflurane anesthesia This activation was assessed by plasma myeloperoxidase and elastase measurements in four consecutive blood samples during and after surgery (before surgical incision and 1, 3, 24 hours following tourniquet release.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Screening
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Total knee arthroplasty under spinal or sevoflurane anesthesia
排除标准
- •American Society of Anesthesiologists class 3 and 4
- •vascular disease of the lower limbs
- •cardiac or respiratory disease
- •immune disorder
研究组 & 干预措施
Group Spinal anesthesia
Knee surgery under spinal anesthesia
Intervention involves spinal administration of 12,5 mg bupivacaine and 2,5 microgram sufentanil.
干预措施: Bupivacaine / SUFentanil (Drug)
Group Sevoflurane anesthesia
Knee surgery under sevoflurane anesthesia
Intervention involves administration of inhaled sevoflurane for maintenance of general anesthesia
干预措施: Sevoflurane Volatile Liquid (Drug)
结局指标
主要结局
Changes in plasmatic concentration of myeloperoxidase and elastase
时间窗: Before surgical incision then 3 and 24 hours after tourniquet release
Biological measurement of changes in plasmatic concentration of myeloperoxidase and elastase from preoperative values to 3 and 24 hours after tourniquet release.
次要结局
- Changes in plasmatic concentration of endothelial biomarkers(Before surgical incision then 3 and 24 hours after tourniquet release)
研究者
Gregory Minguet
Medical Doctor, Anesthesiologist, Principal Investigator
University of Liege