Tear Cytokine Analysis as a Prediction or Diagnostic Marker in Ocular GvHD
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 21
- 试验地点
- 1
- 主要终点
- tear cytokine
研究概览
简要总结
Investigate the profiles of tear cytokines in patients who underwent stem cell transplantation (SCT) and attempted to determine the applicability of tear cytokines in the diagnosis of chronic graft-versus-host disease (GVHD). Evaluate tear cytokines as biomarkers of chronic ocular GVHD severity.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •The patients patients aged 20-60 years who visited the clinic 3-12 months after SCT were included in the study.
排除标准
- •The patients with histories of ocular surgery; ocular injury; and ocular diseases such as ocular infection, allergy, and autoimmune disease, as well as patients with long-term use of topical ocular medications except artificial tears.
结局指标
主要结局
tear cytokine
时间窗: 3-12 month after SCT
comparison of tear cytokines (IL-2,4,10,17a, INF-r, TNF-a) concentrations in patients with or without newly diagnosed chronic GVHD after SCT using a multiplex immunobead assay
tear film break-up time
时间窗: 3-12 month after SCT
ocular surface disease index
时间窗: 3-12 month after SCT
ocular surface status
时间窗: 3-12 month after SCT
conjunctival injection
时间窗: 3-12 month after SCT
Schirmer's test I
时间窗: 3-12 month after SCT
次要结局
未报告次要终点