A Study of Colorectal Cancer Development and Prognosis Based on Environmental Factors and Macrogenomes
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- prognosis
研究概览
简要总结
The aim of this study is to investigate the effects of environmental factors, such as air pollution, on the occurrence, development and prognosis of colorectal cancer; to identify metabolic markers specific to colorectal cancer patients, which will provide a basis for early diagnosis, early intervention and individualized treatment; and to comprehensively understand the mechanism of the occurrence and development of colorectal cancer by integrating the data of environmental factors and the macro-genome, and to develop new predictive and therapeutic strategies.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age ≥18 years old;
- •Patients diagnosed with colorectal cancer by pathologic biopsy before surgery;
- •Patients did not undergo chemotherapy, radiotherapy, targeted and immunotherapy, etc. before enrollment;
- •Willing to participate in the study and sign an informed consent form. Complete clinical data.
排除标准
- •Concurrent primary malignant tumor other than colorectal cancer;
- •Patients with severe cardiopulmonary insufficiency or other systemic diseases that affect the choice of treatment plan;
- •Inappropriate for enrollment as assessed by the investigator;
- •Incomplete clinical data.
结局指标
主要结局
prognosis
时间窗: From date of diagnosis until the date of death from any cause or or loss to follow-up, whichever came first, assessed up to 60 months
Overall survival (OS), from date of diagnosis until the date of death from any cause or or loss to follow-up, whichever came first.
次要结局
- Macrogenomic differences(The date of macrogenomic testing, assessed up to 1 week after surgery.)
研究者
Dong Peng
Principal Investigator
First Affiliated Hospital of Chongqing Medical University