In critically ill patients with acute kidney injury does continuous renal replacement therapy (CRRT) using a machine controlled citrate protocol compared to a regional heparin protcocol improve safety and extend filter life.

Dr. Matthew Brain0 个研究点目标入组 200 人开始时间: 2012年7月18日最近更新: 2020年1月13日

适应症

试验速览

暂无简介。

•Greater than 18 years old
•Diagnosis of acute renal failure with an indication for renal replacement therapy as assessed by one or more of the following criteria:Oliguria (urine output < 100ml in a 6hour period) unresponsive to fluid resuscitation;volume overload, not correctable by diuretics in spite of adequate blood pressure and creatinine > 100umol.L; increase of serum creatinine > 300 umol/L or BUN > 25mmol/L;increase of serum potassium > 6.5 mmol/L due to AKI

•Patient weight < 30kg (determined by machine specification)
•Inability to enter randomization due to a contraindication to one of the treatment arms:
•Indication for systemic anticoagulation with heparin (therapeutic range APTT) or an equivalent therapeutic dose of low molecular weight heparin (note this does not include routine thromboprophylaxis with these agents)
•Prior development of HIT
•History of anaphylaxis to heparin, protamine or citrate.
•Pregnancy, or lactation.
•Patients on chronic renal replacement therapy prior to ICU presentation.
•Indication for therapeutic hypothermia
•Previous participation in the same study
•Indication for a filter set other than the AN69 ST100 1m2 set or a specific dialysis prescription differing from the study protocol (as deemed by the treating physician)

发起方

Dr. Matthew Brain