NCT02188342已完成不适用
Effectiveness of Short Term, High Intensity, Interval Exercise Training in Older Colorectal Cancer Patients in Improving Preoperative Fitness
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 18
- 试验地点
- 2
- 主要终点
- VO2 peak
研究概览
简要总结
The primary aim of this study is to determine whether an improvement in aerobic fitness, as judged by an increase in VO2peak, can be achieved within 31 days via HIT programme in a group of older, colorectal cancer patients.
详细描述
12 high intensity interval training exercise sessions on a static cycle ergometer, over a period of 31 days. Each session lasts 18 minutes.
At the beginning and end of the study the following measures will be used to assess change in fitness, body composition and muscle metabolism. DXA scan, USS of thigh, VO2 peak cycling test, short performance battery tests, quality of life questionnaires and muscle biopsy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 88 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Confirmed colorectal cancer
- •Offered curative treatment by the Royal Derby Hospital NHS Foundation Trust Colorectal Cancer Multidisciplinary Team
- •Male and female
- •18-88 years of age
排除标准
- •Uncontrolled hypertension (BP > 160/100),
- •Heart failure (class III/IV),
- •Cardiac arrthymias,
- •Right to left cardiac shunt,
- •Recent cardiac event,
- •Previous stroke/TIA,
- •Aneurysm (large vessel or intracranial),
- •Severe respiratory disease including pulmonary hypertension,
- •COPD/asthma with an FEV1 less than 1.5 l,
- •Coagulation disorders,
- •Scarring disorders.
- •Current neoadjuvant chemo/radiotherapy
- •Inability to complete the consent process Involvement in invasive research study in previous 3 months.
研究组 & 干预措施
HIT exercise training
Experimental
干预措施: HIT (Behavioral)
结局指标
主要结局
VO2 peak
时间窗: After 31 days of HIT
Mean difference in VO2 peak following a HIT programme
次要结局
- Anaerobic threshold(After 31 days of HIT)
- Muscle protein synthesis(After 31 days of HIT)
- Feasibility(After 31 days of HIT)
- Quality of life(After 31 days of HIT)
- Body composition(After 31 days of HIT)
研究者
研究点 (2)
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