the influence of remote ischemic preconditioning on inflammation during human endotoxemia, a pilot proof-of-principle study - RISPENDO

Intensive Care0 个研究点目标入组 30 人开始时间: 待定最近更新: 2024年4月23日

适应症

试验速览

暂无简介。

•Use of any medication
•Use of recreational drugs within 21 days prior to endotoxemia experiment day
•Use of caffeine or alcohol within 1 day prior to endotoxemia experiment day
•Previous participation in a trial where LPS was administered
•Surgery or trauma with significant blood loss or blood donation within 3 months prior to endotoxemia experiment day
•Participation in another clinical trial within 3 months prior to endotoxemia experiment day
•History, signs, or symptoms of cardiovascular disease
•History of frequent vaso-vagal collapse or of orthostatic hypotension
•History of atrial or ventricular arrhythmia
•Hypertension (RR systolic>160 or RR diastolic>90)
•Hypotension (RR systolic<100 or RR diastolic<50)
•Conduction abnormalities on the ECG consisting of a 1st degree atrioventricular block or a complex bundle branch block
•Renal impairment: plasma creatinine>120 µmol/L
•Liver function abnormality: alkaline phosphatase>230 U/L and/or ALT>90 U/L
•History of asthma
•Obvious disease associated with immune deficiency
•CRP > 20 mg/L
•WBC> 12x109/L or clinically significant acute illness, including infections, within 4 weeks before endotoxemia day

发起方

Intensive Care