Salivary and Serum Levels of Chemerin and MMP-9 in Oral Precancer and Oral Squamous Cell Carcinoma.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 45
- 主要终点
- salivary levels of chemerin in patients with oral premalignant and malignant lesions.
研究概览
简要总结
45 individuals were subdivided into 3 groups, 15 patients with oral premalignant lesions, 15 patients with oral malignant lesions and 15 control individuals. Levels of chemerin and MMP-9 were evaluated in serum and saliva of these subjects utilizing the ELISA technique.
详细描述
45 individuals were subdivided into 3 groups, 15 patients suffering from oral premalignant lesions, 15 patients suffering from oral malignant lesions and 15 individuals having age, gender and periodontal status matched with both patients groups acting as a control group. Serum and whole unstimulated saliva samples were collected from all the included groups in order to determine chemerin and MMP-9 in serum and saliva utilizing the ELISA technique.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 40 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •patients with oral premalignant lesions.
- •patients with oral malignant lesions.
排除标准
- •any systemic disease other than oral premalignant or malignant lesions. smokers. pregnant females. periodontal diseases.
结局指标
主要结局
salivary levels of chemerin in patients with oral premalignant and malignant lesions.
时间窗: 1 day
次要结局
- serum levels of chemerin in patients with oral premalignant and malignant lesions.(1 day)
- serum levels of MMP-9 in patients with oral premalignant and malignant lesions.(morning visit)
- salivary levels of MMP-9 in patients with oral premalignant and malignant lesions.(1 day)
研究者
Noha Ayman Ghallab
Associate Professor of periodontology and Oral Medicine, faculty of oral and dental medicine
Cairo University