Pro-Nociceptive and Anti-Nociceptive Mechanisms Across an Episode of Recurrent Low Back Pain
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Temporal Summation of Pain
研究概览
简要总结
This study evaluates psychophysical measures of pain inhibition and facilitation, along with cortical responses to different sensory stimuli, in patients with recurrent low back pain and matched healthy individuals.
详细描述
Pain inhibitory and facilitatory mechanisms have been suggested to play a role in the development of persistent low back pain; however, there is still debate on when changes in these mechanisms occur. Similarly, evoked cortical responses can reflect neuroplastic changes in pain processing regions, which are also thought to play a role in the transition to persistent pain, but there is also debate on when these neuroplastic changes develop relative to low back pain. Therefore, this study will use patients with an intermediary clinical pain state, recurrent low back pain, and matched healthy control participants, to investigate within and between subject differences in pain inhibitory, facilitatory and neuroplastic mechanisms.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Temporal Summation of Pain
时间窗: Day 0 vs. Day 28
Pain rating (VAS) change over a series of 10 repeated mechanical stimuli
Conditioned Pain Modulation
时间窗: Day 0 vs. Day 28
Pressure pain threshold (kPa) as test stimulus before compared to during a pressure conditioning stimulus on the lower leg
次要结局
- Pressure Pain Thresholds(Day 0 vs. Day 28)
- Thermal Pain Thresholds(Day 0 vs. Day 28)
- Proprioceptive Weighting(Day 0 vs. Day 28)
- Two Point Discrimination(Day 0 vs. Day 28)
- Sensory Evoked Potentials(Day 0 vs. Day 28)
研究者
Megan McPhee
PhD Fellow
Aalborg University