The Impact of Sucrose Ingestion During Exercise on Liver and Muscle Glycogen Concentration.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 14
- 试验地点
- 2
- 主要终点
- Change in liver glycogen concentration
研究概览
简要总结
Carbohydrate is stored in the body as glycogen, which is mainly found in the liver and muscle. During endurance exercise, muscle glycogen is used as fuel for the working muscles and liver glycogen is broken down to provide glucose to maintain blood glucose (sugar) levels. Both liver and muscle glycogen are important for the ability to perform intense/prolonged endurance exercise. Therefore, nutritional strategies which can maximise the availability of glycogen in muscle and liver can benefit endurance exercise capacity.
The carbohydrates typically found in sports drinks are glucose and sometimes fructose. If glucose only is ingested during exercise, then the maximum rate at which can be absorbed from the intestine into the blood stream is ~1 g/min. However, if different sources of carbohydrate (fructose) are used, which are absorbed through a different pathway, absorption of carbohydrate can be up to ~1.8 g/min. With more carbohydrate available as a fuel, this translates into an improvement in performance.
Sucrose is a naturally occurring sugar that is made up of a single glucose and single fructose molecule. Therefore, theoretically, this can use the two different pathways of absorption and also maximise carbohydrate delivery. It is not yet known however, what impact this has on our liver and muscle glycogen stores during exercise. Therefore the aim of this study is to assess whether sucrose ingestion influences liver and muscle glycogen depletion during endurance exercise.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 35 Years(Adult)
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •18 - 35 years of age
- •Endurance trained cyclist/triathlete
- •VO2 max ≥ 50 ml/kg/min
排除标准
- •Use of medication
- •Metabolic disorders
结局指标
主要结局
Change in liver glycogen concentration
时间窗: 3 hours
The change in liver glycogen concentration will be determined pre-to-post 3 h of exercise using 13C magnetic resonance spectroscopy.
次要结局
- Plasma glucose concentration.(3 hours)
- Plasma non-esterified fatty acid concentration(3 hours)
- Indirect calorimetry(3 hours)
- Change in intramyocellular lipid concentration(3 hours)
- Plasma lactate concentration(3 hours)
- Muscle glycogen concentration(3 hours)
研究者
Javier Gonzalez, PhD
Research Fellow
Northumbria University
