Sevoflurane vs Nitrous Oxide Inhalation at Subanesthetic Concentrations
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- Pain intensity
研究概览
简要总结
The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. Comparisons between nitrous oxide, opiates, and benzodiazepine antagonists will be made. To examine sevoflurane versus isoflurane inhalation at subanesthetic concentrations on mood, pain, and psychomotor performance.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Crossover
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 21 Years 至 39 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
研究组 & 干预措施
0.3% sevoflurane
干预措施: 0.3 % Sevoflurane (Drug)
Placebo
Subject inhales no drug (100% oxygen)
干预措施: Placebo (Other)
0.6% sevoflurane
干预措施: 0.6% Sevoflurane (Drug)
15% Nitrous oxide
干预措施: 15 % Nitrous oxide (Drug)
30% Nitrous oxide
干预措施: 30% Nitrous oxide (Drug)
结局指标
主要结局
Pain intensity
时间窗: 30 min of inhalation
Subjects underwent a 3 min cold immersion test at 30 min of inhalation and then provided response to pain intensity questionnaire
Psychomotor performance
时间窗: Baseline, 5 min of inhalation; 5, 30, 60 minutes recovery
Subjects underwent psychomotor testing at baseline, during inhalation, and during recovery post inhalation
Cognitive performance
时间窗: Baseline, every 5 min during inhalation, 5, 30, & 60 min during recovery
Subject underwent memory, sedation, visual analog, and drug effects testing
次要结局
未报告次要终点