Comparison of Effect-site Concentration of Remifentanil for Preventing Cough Against Endotracheal Tube During Anesthetic Emergence According to Anesthetics (Sevoflurane, Desflurane, and Propofol)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 78
- 试验地点
- 1
- 主要终点
- occurrence of cough
研究概览
简要总结
It has been reported that target-controlled infusion of remifentanil can reduce cough against endotracheal tube during emergence from general anesthesia. We hypothesized that effective concentration of remifentanil for preventing cough during anesthetic emergence varies depending on the type of main anesthetic agents which is administered with remifentanil during general anesthesia. The purpose of this study is to evaluate the effective concentrations of remifentanil to prevent coughing during emergence from general anesthesia according to main anesthetic agent (sevoflurane, desflurane, and propofol).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 60 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •aged 20-60
- •ASA classification I~II
- •female patients
- •patients who undergoing thyroidectomy
排除标准
- •Patients with acute or chronic respiratory disease
- •patient who has smoking history
- •patient who has hypertension
- •patient who has esophageal reflux
- •patient who having an expectorant or cough remedy
研究组 & 干预措施
Sevo group
undergoing sevoflurane-remifentanil anesthesia
干预措施: up-and-down method to find out effective concentration of remifentanil for preventing cough (Drug)
Des group
undergoing desflurane-remifentanil anesthesia
干预措施: up-and-down method to find out effective concentration of remifentanil for preventing cough (Drug)
Pro group
undergoing propofol-remifentanil anesthesia
干预措施: up-and-down method to find out effective concentration of remifentanil for preventing cough (Drug)
结局指标
主要结局
occurrence of cough
时间窗: From the completion of surgery to 5minute after extubation
We will assess the occurrence of cough during emergence from general anesthesia in female patients undergoing target controlled infusion of remifentanil at predetemined concentration.
次要结局
未报告次要终点