NL-OMON46412招募中不适用
Effect of positive transpulmonary pressures on intracranial pressure and cerebrovascular autoregulation in severe acute brain injury - Effect intrathoracic pressures on intracranial pressures
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 20
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •Age * 18 years
- •Severe TBI defined as Glasgow Coma Score 3-8
- •Multimodal neuromonitoring, including at least intracranial pressure monitoring
- •Acute respiratory distress syndrome (ARDS, according to the Berlin definition)
排除标准
- •- Hemodynamic instability, despite fluid resuscitation and/or vasopressor use.
- •- Pneumothorax in last 3 days before the start of the study
- •- Signs and/or symptoms of brain herniation based on clinical symptoms and or CT cerebrum
- •- Pregnancy
- •- Status after decompressive craniectomy
- •- During or after Penthotal coma
- •- Unfavourable ventilator settings before start of the study (defined as plateau pressures > 30 cm H2O, or FiO2 > 60%)
- •- Intracranial pressure > 20 mmHg for at least 5 minutes, despite the use of ICP lowering treatment
- •- Moribund (fixed pupils or signs of brainstem coning)
- •- History of oesophageal surgery
研究者
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