Prospective Randomized Trial on GnRH Agonist Triggering Versus hCG Triggering in IVF Stimulation in PCOS Patients
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- MII oocytes
研究概览
简要总结
In this study the investigators compare the traditional way of triggering with a new way in patients with Poly Cystic Ovary Syndrome (PCOS). This to reduce the risque of Ovary Hyper Stimulation Syndrome (OHSS) in In Vitro Fertilization/ IntraCytoplastic Sperm Injection (IVF/ ICSI) treatment. The investigators also compare the number of mature oocytes, embryo's and pregnancy rate.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 38 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •ICSI patients below 38 years
- •1, 2 and 3e IVF cycle
- •Body Mass Index (BMI) less than 32
- •PCOS patients
排除标准
- •endocrinal diseases or problems
研究组 & 干预措施
GnRH agonist + 1500E hCG
ovulation induction with GnRH agonist and 1500E hCG one hour after egg retrieval
干预措施: GnRh agonist +1500E hCG (Drug)
结局指标
主要结局
MII oocytes
时间窗: patients will be followed during the stimulation with an average of 10 days
The number of mature oocytes retrieved after stimulation without creating OHSS
2 Pro Nuclei (2PN) fertilization
时间窗: 24h after ICSI
laboratory follow up of the fertilized egg during the first 24h
次要结局
- implantation rate(12 weeks)
- OHSS(one month with oocyte retrieval in the middle)
研究者
Dr. Decleer Wim
gynecologist
AZ Jan Palfijn Gent