The Effect of Intraperitoneal Injection of Magnesium Sulphate Versus Dexmedetomidine as an Adjuvant to Bupivacaine on Postoperative Analgesia in Patients Undergoing Abdominal Aortic Surgery
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- time for first anelgesic request
研究概览
简要总结
optimal management of postoperative pain is essentiel for better outcome in abdominal aortic surgery.the study aim to compare between analgesic effect of magnesium sulphate versus dexmedetomidine as an adjuvant to bupivacaine when injected intraperitoneal in abdominal aortic surgery.METHODS:50 patients undergoing abdominal aortic surgery are randemelly divided into 2 groups.(group D:patients received 20ml isobaric bupivacaine+1mic/kg dexemedetomidine completed to 5ml normal saline) Group M:patients received 20ml isobaric bupivacaine+5mg magnesuim sulphate .postoperative VAS,MAP will be recorded initially then every 2hours.
详细描述
AIM OF THE study To compare between analgesic effect of magnesium sulphate versus dexmedetomidine as an adjuvant to bupivacaine when injected intraperitoneal in abdominal aortic surgery methods This study conducted on patients scheduled for abdominal aortic surgery under general anesthesia in Mansoura University Hospitals .The duration of the study is approximately 5 months. The operation will be done after informed written consent from all patients.
Inclusion criteria:
- Patients scheduled for abdominal aortic surgery under general anesthesia
- American Society of Anesthesiologists ASA I-III.
- aged 20-60
Exclusion criteria:
- Patients with a history of previous abdominal surgery.
- uncontrolled hypertension or diabetes, major cardiopulmonary disease.
- psychiatric illness . On the operation day, the patients will be transferred to the operative theater, where a peripheral cannula will be inserted in a suitable forearm vein. All patients received IV midazolam 5 mg to decrease their anxiety. Routine hemodynamic monitoring will be connected, including ECG, pulse oximetry, heart rate, and noninvasive blood pressure.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients scheduled for abdominal aortic surgery under general anesthesia
- •American Society of Anesthesiologists ASA I-III.
排除标准
- •Patients with a history of previous abdominal surgery.
- •uncontrolled hypertension or diabetes, major cardiopulmonary disease.
- •psychiatric illness .
- •allergy to study drugs
研究组 & 干预措施
Group D(dexemedetomidine group)
Patients receive 20 mL isobaric bupivacaine 0.25% + 1μg/kg Dexmedetomidine completed to 5ml with normal saline.
干预措施: Dexmedetomidine (Drug)
Group D(dexemedetomidine group)
Patients receive 20 mL isobaric bupivacaine 0.25% + 1μg/kg Dexmedetomidine completed to 5ml with normal saline.
干预措施: isobaric bupivacaine (Drug)
Group M: (magnesuim sulphate group)
Patients received 20ml isobaric bupivacaine 0.25% + 5 ml (500 mg) magnesium sulphate
干预措施: magnesuim sulphate (Drug)
Group M: (magnesuim sulphate group)
Patients received 20ml isobaric bupivacaine 0.25% + 5 ml (500 mg) magnesium sulphate
干预措施: isobaric bupivacaine (Drug)
结局指标
主要结局
time for first anelgesic request
时间窗: 24 hours postoperative
first postoperative time patients request anelgesia
次要结局
- total anelgesic requirement(24 hours postoperative)
研究者
ghada fouad
associate professor of anesthesia
Mansoura University