Effects of Physical-Cognitive Training With Different Task Models in Parkinson's Disease With Mild Cognitive Impairment

Not Applicable

Completed

• Conditions: Mild Cognitive Impairment; Parkinson Disease
• Interventions: Behavioral: Integrated physical-cognitive training; Behavioral: Consecutive physical-cognitive training

• Registration Number: NCT05172661
• Lead Sponsor: National Taiwan University Hospital

Brief Summary

The present study will characterize exercise model effects (integrated model vs. consecutive model) of physical-cognitive exercise on dual-task walking control in Parkinson's disease with mild cognitive impairment.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2021-11-26
• Study First Submitted: 2021-11-29
• Study First Submitted QC: 2021-12-12
• Study First Posted: 2021-12-29
• Primary Completion: 2022-06-30
• Study Completion: 2022-09-30
• Status Verified: 2023-01
• Last Update Submitted: 2023-02-01
• Last Update Posted: 2023-02-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 27

Inclusion Criteria

• a diagnosis of idiopathic Parkinson's disease
• have decreased cognitive functions but do not interfere with functional independence
• Montreal Cognitive Assessment (MoCA): 21-25
• able to walk independently without walking devices for at least 10 meters and with the ability to turn 180°

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Exclusion Criteria

• a diagnosis of dementia
• other diseases that may influence cognitive functions or walking performance
• a history of brain surgery
• modification of the medication during the exercise intervention

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Integrated training model	Integrated physical-cognitive training	Participants in this group will accept postural and cognitive training at the same time, e.g. naming animals while standing on the foam. Each training session will last for 70 minutes, twice a week, and 12 sessions in total.
Consecutive training model	Consecutive physical-cognitive training	Participants in this group will accept postural and cognitive training separately and for identical durations (both 30 minutes). Each training session will last for 70 minutes, twice a week, and 12 sessions in total.

Primary Outcome Measures

Name	Time	Method
Change from baseline dual-task walking performance at 8 weeks	8 weeks
Change from baseline Montreal Cognitive Assessment (MoCA) score at 8 weeks	8 weeks	MoCA: 0-30 points, higher scores mean a better outcome
Fall frequency	20 weeks

Trial Locations

Locations (1)

National Taiwan University; 🇨🇳 Taipei, Taiwan