Effects of Different Types of Exercise on Cognitive Function in Postmenopausal Hypertensive Women
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Cognitive Function
- Sponsor
- Beijing Sport University
- Enrollment
- 183
- Locations
- 1
- Primary Endpoint
- MOCA score
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
Brief Summary: The study was conducted in two parts, the first of which was carried out using a cross-sectional design approach to explore the relationship between cognitive function and autonomic function, brain function, inflammation and oxidative stress, vascular function, fitness levels, cardiorespiratory endurance and lipid metabolism. The second part uses a repeated measures design approach in a randomised controlled design to explore the effects of different types of exercise on cognitive decline in postmenopausal hypertensive women and their mechanisms of action.
Detailed Description
Detailed Description: The study was conducted in 2 parts. Part I: was conducted using a cross-sectional design approach to explore the relationship between cognitive function and autonomic function, brain function, inflammation and oxidative stress, vascular function, fitness levels, cardiorespiratory endurance and lipid metabolism. Multiple linear regression was used to analyse the multiple linear relationships between changes in cognitive function and the above influences. Multiple logistic regression analysis was also used to analyse which of the above risk factors might be independent predictors of cognitive decline. Therefore, a combination of both regression analyses was used to further explore the multiple linear relationships between cognitive function and the aforementioned influencing factors, providing a viable causal and theoretical basis for the next exercise intervention. The second part of the study is to test the viability of the vascular function theory. The "vascular function theory" refers to the use of exercise to improve aerobic capacity, improve blood circulation to the heart, and improve cerebrovascular function, which in turn improves cognitive function. Based on the above hypothesis, this study aims to investigate the possible effects of 12 weeks of different types of exercise on cognitive decline in post-menopausal women with HTN, and to lay the theoretical and practical foundation for the extension of the exercise intervention to other ages and populations.
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
MOCA score
Time Frame: 12 weeks
The change of MOCA score. Montreal cognitive assessment (MoCA). The MoCA scale includes cognitive functions such as visuospatial and executive functions, naming, attention, language, abstraction, delayed recall and orientation, and evaluates the level of cognitive function from several cognitive dimensions. The MoCA has a total score of 30 questions, with 26 being normal and \<26 being cognitive decline.
Secondary Outcomes
- Nitric oxide (NO)(12 weeks)
- Waist and hip circumference(12 weeks)
- Body fat percentage(12 weeks)
- Lipid metabolism indicators(12 weeks)
- Insulin-like growth factor(IGF-1)(12 weeks)
- High-sensitivity C-reactive protein (hs-CRP)(12 weeks)
- Cardiorespiratory endurance indicator(12 weeks)
- Malondialdehyde (MDA)(12 weeks)
- Peak systolic velocity (PSV) and end-diastolic velocity (EDV) of carotid artery(12 weeks)
- Vascular endothelial function indicator: Flow-mediated dilation (FMD)(12 weeks)
- Serum interleukin-6 (IL-6)(12 weeks)
- Mean flow rate (Vm) of middle cerebral artery and carotid artery(12 weeks)
- Vascular endothelial growth factor (VEGF)(12 weeks)
- Quiet heart rate(12 weeks)
- Superoxide dismutase (SOD)(12 weeks)
- Heart rate variability (HRV)(12 weeks)
- Pulsatility index (PI) of middle cerebral artery and carotid artery(12 weeks)
- Blood pressure(12 weeks)
- Resistance index (RI) of middle cerebral artery and carotid artery(12 weeks)
- Artery stiffness indicator: Carotid-femoral pulse artery stiffness (cfPWV).(12 weeks)