Three methodological aspects in TMS-EEG: Noise masking, pulse intensity and need for accurate coil positioning
Completed
- Conditions
- epilepsyseizures10039911
- Registration Number
- NL-OMON38385
- Lead Sponsor
- niversiteit Twente
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 31
Inclusion Criteria
age between 18 and 60;patients: focal epilepsy
Exclusion Criteria
hearing problems
(possible) pregnancy
metal objects in brain/skull
cochleair implang, implanted brain electrode or pacemaker
severe medical condition
take medications that lower the threshold for seizure
spinal surgery, drains in spinal cord or ventricles
use illegal drugs
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Our main endpoints are the presence and characteristics of the auditory evoked<br /><br>potential, the TMS-MEP and TMS-EEG response.<br /><br><br /><br>Auditory evoked potential<br /><br>o Amplitude (microV)<br /><br>o Latency (msec)<br /><br><br /><br>MEP<br /><br>o Amplitude (mV)<br /><br>o Latency (msec)<br /><br>o Motor Threshold (Tesla)<br /><br><br /><br>TMS-EEG response<br /><br>o Amplitude of peaks (microV)<br /><br>o Latencies of peaks (msec)</p><br>
- Secondary Outcome Measures
Name Time Method <p>TMS-EEG response: Additional signal analysis methods, including wavelet<br /><br>analysis of early and late TMS-EEG responses and the spatiotemporal<br /><br>characteristics of the TMS-EEG response.<br /><br><br /><br>In the epilepsy patients, we will record the number of epileptic abnormalities<br /><br>in the EEG before and after the TMS experiment. </p><br>