The value of simultaneous TMS-EEG recordings for diagnostic purposes in epilepsy patients

Withdrawn

Conditions: falling sickness
seizure disorder
10039911

Registration Number: NL-OMON43343

Lead Sponsor: Epilepsiecentrum Kempenhaeghe

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Withdrawn

Sex: Not specified

Target Recruitment: 20

Inclusion Criteria

* Patients and healthy volunteers need to be 18 years or older and should be able to perceive magnetic stimulation, i.e. do not fulfil any of the exclusion criteria as mentioned in section 4.3.
* The patients included should be candidate for a video-EEG recording as part of their pre-surgical investigations.
* The decision for withdrawal of AEDs is a clinical decision, which is not influenced by the protocol requirements of this study.
* The patients included all are selected to have a pre-surgical simultaneous EEG and fMRI investigation.

Exclusion Criteria

* Serious head trauma or brain surgery
* Large or ferromagnetic metal parts in the head (except for a dental wire)
* Implanted cardiac pacemaker or neurostimulator
* Pregnancy
* Skin diseases at intended electrode sites (EMG, EEG, TMS)

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary study parameter is that changes in excitability of the brain<br /><br>studied with MEPs evoked by TMS, are reflected in the EEG either as evoked<br /><br>discharges or as increased rsFC. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>A secondary endpoint is the rejection of the null-hypothesis that the<br /><br>excitability of the brain is not increased in the condition without the use of<br /><br>AEDs compared to the condition that the patient is on the steady-state<br /><br>maintenance doses of AEDs as prescribed.</p><br>