Conditioning of the Cortisol Awakening Response (CAR)

Completed

Conditions: Het onderzoek wordt bij gezonde mensen uitgevoerd. Uitkomsten uit deze lijn van onderzoek bieden nieuwe handvatten voor therapeutische interventies voor patiënten met verlate slaap-fase syndroom of seizoensgebonden depressie.
Not applicable

Registration Number: NL-OMON50199

Lead Sponsor: niversiteit Leiden

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 88

Inclusion Criteria

* Male gender
* Aged between 21 and 34 years of age
* Good understanding of written and spoken Dutch.

Exclusion Criteria

* Refusal to give written informed consent
* Severe somatic or psychiatric conditions that would adversely affect
participant*s safety or that might interfere with the study protocol
* Olfactory impairments
* Known sensitivity or hypervigilance to one of the ingredients of the scents
used in this experiment
* Heavy use of (illegal) drugs including cannabis and habits of heavy drinking
* Irregular sleep pattern or sleep problems
* Use of medication that interferes with the study protocol
* Factors known to influence the CAR:
o Having an acute illness, or experienced an illness in the past seven days
(e.g. influenza, common cold)
o Experienced jet lag or shift work in the past seven days
o Use of (oral) glucocorticoid medication
o HPA-axis related endocrine disorders (e.g., Cushings disease or Addisons
disease)
o Brain damage, particularly hippocampal brain damage
o Obesity

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameter is change in the CAR (evocation measurement compared<br /><br>to baseline measurement) in the experimental compared with the control group.</p><br>

Secondary Outcome Measures