Impact of clinical efficacy of probiotics in hemodialysis patients.
- Conditions
- Chronic renal failure patients receiving hemodialysis
- Registration Number
- JPRN-UMIN000031365
- Lead Sponsor
- Tokyo Women's Medical University
- Brief Summary
The ratio of CRP to albumin did not change before and after treatment in both groups. The serum phosphate levels in the Bio-Three group significantly decreased after 6-month treatment, while did not change in the placebo group. In a 16s rRNA gene-based sequencing protocol analysis, the ratio of Firmicutes, Actinomycetales and Neisseriaies significantly changed after 6 month treatment in the only probiotic group.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 80
Not provided
1 Patients who received peritoneal dialysis 2 Patients whose serum CRP levels were 1.0 mg/dl and over within 1 week 3 Patients who took ethical drugs including probiotics within 1 week 4 Patients with an infection or a sign of an infection within 1 week 5 Patients with an inflammatory disease or a sign of an inflammatory disease 6 Patients with a past history of hypersensitivity to BIO-THREE component 7 Patients considered as inadequate human subjects by the principal investigator
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To evaluate the changes of the ratio of CRP to albumin before and after administration of probiotics products.
- Secondary Outcome Measures
Name Time Method 1. Intestinal flora (next generation sequence) 2. ALP isozyme 3. Serum level of ALP 4. The small intestine gas