The impact of the macronutrient composition of a nutritional supplement on postprandial skeletal muscle protein synthesis in elderly

Phase 2

Completed

• Conditions: Onderzoek vindt plaats in gezonde ouderen en ouderen met sarcopenie; Sarcopenia; age-related loss of muscle mass and muscle function; 10028302

• Registration Number: NL-OMON39327
• Lead Sponsor: utricia Danone Research - Centre for Specialised Nutrition

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 60

Inclusion Criteria

- Age 65 y or older
- Male
- Healthy (n = 45) or sarcopenia (n = 15)
- BMI from 20 through 30 kg/m2
- Written informed consent

Exclusion Criteria

- Indications related to inadequate glycemic control
- All co-morbidities interacting with mobility and/or muscle metabolism of the lower limbs
- Any (history of) gastrointestinal disease that interferes with GI function
- Diabetes Mellitus type I or II
- Adherence to a weight loss diet
- Use of protein containing or amino acid containing nutritional supplements within one week of study entry
- Participation in any regular exercise program focusing on improving skeletal muscle mass
- Known allergy to milk and milk products
- Known galactosaemia
- Blood diseases, use of anticoagulants or allergy for lidocaine, because of muscle biopsy collection

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Mixed muscle protein fractional synthetic rate (FSR) [%/h]</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Plasma leucine (Leumax [umol/L]; LeuiAUC [umol/(L*min)])<br /><br>Plasma essential amino acids (EAAmax [umol/L]; EAAiAUC [umol/(L*min)])</p><br>