Comparison of Spinal Anesthesia Adjuvant and Quadratus Lumborum Block on the Opioid Requirement and Perioperative Pain of Laparoscopic Kidney Transplant Donor
Not Applicable
Recruiting
- Conditions
- Laparoscopic Donor NephrectomyPerioperative Pain Management
- Registration Number
- NCT06764667
- Lead Sponsor
- Indonesia University
- Brief Summary
This study aims to compare the effectiveness of spinal anesthesia adjuvant and quadratus lumborum block on the opioid requirement and perioperative pain on patients undergoing laparoscopic kidney transplant donor.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
- Patients aged 18-65 years undergoing laparoscopic donor nephrectomy
- Patients with BMI ≤ 35 kg/m2
- Patients with American Society of Anesthesiology (ASA) physical status 1-2
- Patients who are willing to participate in this study
Exclusion Criteria
- Cardiovascular disease (uncontrolled stage 2 hypertension, heart failure, arrhytmia)
- Recent onset cerebrovascular diseasae of < 3 months
- Infection on spinal site
- Coagulopathy
- Elevated intracranial pressure
- Severe renal or liver dysfunction
- Valvular heart disease or atrioventricular block
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Postoperative pain Hour 2, 6, 12, and 24 Postoperative pain measured with Numerical Rating Scale (NRS) during rest and movement.
Opioid requirement Hour 2, 6, 12, and 24 Morphine requirement on Patient-Controlled Analgesia (PCA).
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie the opioid-sparing effect of spinal anesthesia adjuvants versus quadratus lumborum blocks in laparoscopic donor nephrectomy?
How does the combination of spinal anesthesia adjuvants and quadratus lumborum blocks compare to standard multimodal analgesia in reducing postoperative opioid consumption for kidney transplant donors?
Are there specific biomarkers or patient characteristics that predict superior pain control with quadratus lumborum blocks over spinal anesthesia adjuvants in laparoscopic donor nephrectomy?
What are the differential adverse event profiles of spinal anesthesia adjuvants versus quadratus lumborum blocks in patients undergoing laparoscopic donor nephrectomy?
How do regional anesthetic techniques like quadratus lumborum blocks influence long-term chronic pain outcomes compared to spinal anesthesia in kidney transplant donors?
Trial Locations
- Locations (1)
RSUP dr. Cipto Mangunkusumo
🇮🇩Jakarta Pusat, Jakarta, Indonesia