Comparison of effectiveness of norepinephrine andphenylephrine when given as a single bolus dose for treatment of fall in blood pressure during planned caesarean section under spinal anaesthesia
Phase 4
Completed
- Conditions
- Health Condition 1: null- Spinal Anaesthesia induced Hypotension in Elective caesarean section
- Registration Number
- CTRI/2016/12/007542
- Lead Sponsor
- niversity College of Medical Sciences and Guru Teg Bahadur Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 100
Inclusion Criteria
Healthy females with term, uncomplicated, singleton pregnancy undergoing elective caesarean section under spinal anaesthesia
Exclusion Criteria
Maternal complications e.g. diabetes, pre-eclampsia, other cardiovascular disease, cerebrovascular disease; multiple gestation; known fetal abnormality; patients with absolute or relative contra-indications for spinal anaesthesia e.g. infection in lumbar area, coagulation abnormalities, autonomic neuropathy, spinal deformities, other neurological diseases; hypovolemia due to any cause; maternal baseline SBP less than 100 mmHg; patients on monoamine oxidase inhibitors or tricyclic antidepressants; presence of mesenteric or peripheral vascular thrombosis
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To determine potency ratio of norepinephrine and phenylephrine, administered as bolus for treatment of post-spinal hypotension during elective caesarean section, by calculating the ratio between ED95 of norepinephrine and phenylephrineTimepoint: One minute after injection of vasopressor drug
- Secondary Outcome Measures
Name Time Method To determine potency ratio of norepinephrine and phenylephrine, administered as bolus for treatment of post-spinal hypotension during elective caesarean section, by calculating the ratio between ED50 of norepinephrine and phenylephrine.Timepoint: One minute after injection of vasopressor drug