Can a drug that improves blood flow and oxygen supply to the heart improve outcomes during and after heart surgery?

Not Applicable

Completed

• Conditions: Heart failure; Circulatory System

• Registration Number: ISRCTN17397629
• Lead Sponsor: IVERSIDAD LA FRONTERA

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2017-05-01
• Study Start: 2019-06-24
• Last Update Posted: 3 February 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

1. Aged over 18 years
2. Off-pump cardiac surgery
3. Left ventricular ejection fraction =40%
4. New York Heart Association classification III-IV
4. IC =2.5 L
5. American Society of Anaesthesiologists (ASA) physical status classification II or III

Exclusion Criteria

1. Patients with liver or kidney failure.
2. Patients requiring coronary revascularization with extracorporeal circulation.
3. Candidates for cardiac reoperation.
4. Patients with hemodynamic instability, cardiogenic shock.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<br> 1. Heart failure is recorded if CI <2.0 L/minm2 up to 48 hours postoperatively.<br> 2. Low cardiac output defined 2 L/min/m2. Cardiac index is calculated from cardiac output,<br> which is measured using the thermodilution technique via the Swan-Ganz catheter up to 48<br> hours postoperatively.<br>