Examining the Relationship Between Respiratory Muscle Fatigue and Lower Extremity Muscle Oxygenation in Chronic Obstructive Pulmonary Disease Patients.
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Lower extremity muscle oxygenation level measurement
研究概览
简要总结
In our study, changes in vastus lateralis muscle oxygenation will be evaluated with the Moxy device, a functional infrared oxygen measurement device, during the inspiratory muscle fatigue protocol in COPD cases and the healthy control group.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Having a diagnosis of Stage 2-3 COPD according to the following clinical diagnostic criteria according to the American Thoracic and European Respiratory Societies (ATS-ERS).
- •Having been using the same medications for the last 4 weeks
排除标准
- •Patients with severe comorbid diseases, unstable coronary artery disease, collagen vascular diseases and requiring high-flow oxygen therapy (˃ 3-4 L\min).
- •Presence of any vascular problem that may affect lower extremity muscle oxygenation
- •Presence of another respiratory system disease other than COPD
- •Patients who have had an acute COPD exacerbation in the last 4 weeks
- •Patients experiencing COPD exacerbations during the study protocol
- •Presence of fatty tissue or scar tissue at the measurement points, which may impair the measurement quality.
- •Have already participated in another clinical trial within the last 30 days that may affect the results of the study.
- •Inclusion Criteria for Healthy Cases
- •Being over 18 years of age
- •Not having any diagnosed chronic disease
- •Not being a smoker
结局指标
主要结局
Lower extremity muscle oxygenation level measurement
时间窗: 20 minutes
Near Infrared Reflection Spectroscopy device will be used. The device measures and monitors muscle oxygen by taking the reflected rays of infrared rays given to the body from two different sensors to measure muscle oxygenation levels in muscle tissue. The measurement will be made in the dominant lower extremity, and the device will be placed in the mid-thigh region at the distance between the spina iliaca anterior superior reference point and the midpoint of the patella.
Lower extremity muscle total hemoglobin amount level measurement
时间窗: 20 minutes
Near Infrared Reflection Spectroscopy device will be used. The device measures and monitors muscle total hemoglobin amount by taking the reflected rays of infrared rays given to the body from two different sensors to measure muscle oxygenation levels in muscle tissue. The measurement will be made in the dominant lower extremity, and the device will be placed in the mid-thigh region at the distance between the spina iliaca anterior superior reference point and the midpoint of the patella.
次要结局
- Peripheral oxygen saturation measurement(20 minutes)
- Forced vital capacity (FVC),(5 minutes)
- Forced expiratory volum in one second (FEV1)(5 minutes)
- Respiratory muscle strength(10 minutes)
研究者
esra pehlivan
Principal Investigator
Saglik Bilimleri Universitesi