The Effect of Infraclavicular Block on Tourniquet-Induced Ischaemia Reperfusion Injury

Not Applicable

Completed

• Conditions: the periferal nerve block for tourniquet-induced ischaemia reperfusion injury; Anaesthesiology - Other anaesthesiology

• Registration Number: ACTRN12621000475842
• Lead Sponsor: Selcuk University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2020-01-31
• Study Start: 2021-04-21
• Last Update Posted: 26 April 2021

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

Sixty number of males and females, aged between 18 and 65 y with ASA physical status I–III undergoing routine upper extremity surgery with a pneumatic tourniquet..

Exclusion Criteria

cardiac, metabolic, renal, or hepatic diseases; systemic rheumatological diseases; inflammatory, autoimmune, or peripheral vascular diseases; symptomatic diabetic microangiopathy (diabetic foot, diabetic retinopathy, etc.); known limb ischemia; deep vein thrombosis; or hemodynamic instability. Additional exclusion criteria were a history of cancer, a history of coronary artery disease within the previous year or extremity surgery within the previous 3 months, drug use that could impair the acid-base balance, steroid drug use, alcohol consumption and smoking.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<br>Comparison of serum total antioxidant status (TAS) levels between two groups according to T1 and T2 times.[ T1 values before tourniquet application, and T2 values 2 hour after tourniquet opening.];Comparison of serum total oxidant status (TOS) levels between two groups according to T1 and T2 times.[T1 values before tourniquet application, and T2 values 2 hour after tourniquet opening.];Comparison of serum ischemia-modified albumin (IMA) levels between two groups according to T1 and T2 times.[T1 values before tourniquet application, and T2 values 2 hour after tourniquet opening.]

Secondary Outcome Measures

Name	Time	Method
Comparison of serum TAS level between and within the groups according to 0-60 minutes the tourniquet times.<br>[T1 values before tourniquet application, and T2 values 2 hour after tourniquet opening.];Comparison of serum TOS level between and within the groups according to the 61-120 minutes tourniquet times.[T1 values before tourniquet application, and T2 values 2 hour after tourniquet opening.];Comparison of serum IMA level between and within the groups according to 0-60 minutes the tourniquet times.[T1 values before tourniquet application, and T2 values 2 hour after tourniquet opening.]