The Effect of Pregabalin on Pain of Propofol Injection
Overview
- Phase
- Not Applicable
- Intervention
- Lidocaine
- Conditions
- Pain
- Sponsor
- Kyungpook National University Hospital
- Enrollment
- 120
- Locations
- 1
- Primary Endpoint
- Propofol injection pain
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
Pain is a common side effect of propofol injection. The purpose of this study was to compare the efficacy of pregabalin and lidocaine in reducing propofol injection pain.
Detailed Description
In a randomized, double blind, prospective trial, 120 patients were allocated to one of three groups (each n=40) receiving intravenous lidocaine 40mg (group L), oral pregabalin 75 mg (group LP), and oral pregabalin 150 mg (group HP) as pretreatment, followed by injection of 25% of 2 mg/kg propofol. Pain was assessed by a four point scale (0=no, 1=mild, 2=moderate, 3=severe pain).
Investigators
Younghoon Jeon
Professor
Kyungpook National University Hospital
Eligibility Criteria
Inclusion Criteria
- •Patient underwent elective dental surgery.
Exclusion Criteria
- •Patient with a history of adverse response to lidocaine or pregabalin,
- •Patient with cardiovascular or respiratory disease,
- •Patient who takes any sedatives, analgesics, or anticonvulsants within 24 hours before surgery.
Arms & Interventions
Group L
Lidocaine 40mg was given intravenously before injection of propofol
Intervention: Lidocaine
Group L
Lidocaine 40mg was given intravenously before injection of propofol
Intervention: propofol
Group LP
Pregabalin 75 mg was given orally 2 hour before surgery
Intervention: Pregabalin
Group LP
Pregabalin 75 mg was given orally 2 hour before surgery
Intervention: propofol
Group HP
Pregabalin 150 mg was given orally 2 hour before surgery
Intervention: Pregabalin
Group HP
Pregabalin 150 mg was given orally 2 hour before surgery
Intervention: propofol
Outcomes
Primary Outcomes
Propofol injection pain
Time Frame: 10 seconds after injection of propofol
Thirty seconds after pretreatment, 25% of the total calculated dose of propofol (2 mg/kg) was administrated into a dorsal hand vein. Ten seconds after injection of propofol, pain was assessed on a four-point scale (0=none, 1 = mild, 2= moderate, 3= severe).