Effect of Preoperative Pregabalin on Propofol Induction Dose
- Registration Number
- NCT01158859
- Lead Sponsor
- Université de Sherbrooke
- Brief Summary
The primary issue is to determine whether preoperatively administered pregabalin decreases the necessary dose of propofol during induction of general anesthesia. The investigators secondary issue is to test if preoperatively administered pregabalin decreases anxiety.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 50
Inclusion Criteria
- Laparoscopic gynaecologic surgery
- Age 18-40 years
- ASA class I or II
- Body mass index 18-30
Exclusion Criteria
- Allergic to pregabalin or gabapentin
- Chronic renal failure
- Alcohol or drug abuse
- Chronic analgesic use other than acetaminophen or NSAID
- Already taking gabapentin, pregabalin, benzodiazepin or antidepression drug
- Known neurological deficiency
- Suspected difficult intubation or ventilation
- Atypical pseudocholinesterases
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo Pregabalin - Pregabalin Pregabalin -
- Primary Outcome Measures
Name Time Method Propofol induction dose 1 hour Evaluation of the hpreoperative pregabalin Vs placebo effect on propofol induction dose needed to induce general anesthesia assessed by entropy in gynaecologic patients undertaking minor surgical procedure.
- Secondary Outcome Measures
Name Time Method Preoperative anxiety 1 hour Evaluation of the effect of pregabalin Vs placebo on preoperative anxiety
Trial Locations
- Locations (1)
Centre Hospitalier Universitaire de Sherbrooke
🇨🇦Sherbrooke, Quebec, Canada