Prefrontal cortex in aging and effect of aquatic therapy-from ANS and executive function perspective (PART II)

Phase 2

• Conditions: elderlyMild cognitive impairment (MCI); Prefrontal cortex; Autonomic nervous system; Executive function; aquatic therapy; cognitive impairment

• Registration Number: TCTR20181116001
• Lead Sponsor: ational Yang Ming Chiao Tung University, Taiwan

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2018-11-16
• Study Completion: 2023-06-30
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: nknown
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

(1) older adults age between 65 and 80 y/o
(2) Mini-mental status examination (MMSE) in no less than 24 points
(3) Montreal cognitive assessment (MoCA) is no less than 24 points as healthy and < 26 as MCI
(4) Walk independently (without assistive devices) for at least 10 m

Exclusion Criteria

(1) Unstable medical conditions
(2) MMSE < 24
(3) Neurological, cardiac disease, or learning disability
(4) Ongoing regular aquatic exercise program
(5) Contraindication for exercise and hydrotherapy

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
prefrontal cortex activity pre-test, post-test, 3-month follow-up, 6-month follow-up function near-infrared spectroscopy (fNIRS),autonomic nervous control pre-test, post-test, 3-month follow-up, 6-month follow-up heart rate variability,executive function pre-test, post-test, 3-month follow-up, 6-month follow-up Trail Making Test A, B,executive function pre-test, post-test, 3-month follow-up, 6-month follow-up Stroop Color and Word Test

Secondary Outcome Measures

Name	Time	Method
single and sual task walking ability pre-test, post-test, 3-month follow-up, 6-month follow-up GAITRite system for spatiotemporal parameters under single task and dual task,fall risk pre-test, post-test, 3-month follow-up, 6-month follow-up the number of fall episodes in the past 6 months,quality of life pre-test, post-test, 3-month follow-up, 6-month follow-up 36-Item Short-Form Health Survey (SF-36)