Activation of prefrontal cortex in elderly people from Okinawa in comparison to elderly from the Nederlands

Completed

• Conditions: cognition; Healthy ageing; 10029305

• Registration Number: NL-OMON48651
• Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 40

Inclusion Criteria

aged between 65 and 80 years old

Exclusion Criteria

1. Current diagnosis of psychiatric or neurological illness
2. MMSE<27
3. Alcohol or drug abuse
4. Not fluent in the Dutch language / Japanese

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1. Differences in frontal brain activation (at equal or better performance<br /><br>levels) on a verbal fluency task compared between Okinawan and Dutch elderly.<br /><br>2. Differences in frontal brain activation (at equal or better performance<br /><br>levels) on memory processing of meaningless shapes between Okinawan and Dutch<br /><br>elderly.<br /><br>3. Differences in leftward lateralisation (as young people do) for brain<br /><br>activation during a verbal fluency task between Okinawan and Dutch elderly.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Correlation of HbO levels and lateralization index with performance on<br /><br>cognitive tests, APOE4 gene variation, SFS scores and PASE scores .</p><br>