A clinical study to know the efficacy of dexmedetomidine used in the nose inhalation on the pain and swelling following unerupted lower jaw third molar tooth removal.
Not Applicable
- Conditions
- Health Condition 1: K011- Impacted teeth
- Registration Number
- CTRI/2022/09/045731
- Lead Sponsor
- RAMADEVI MATTA
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Patients of age 18 - 40 years
Patients with bilaterally similar mandibular third molars
Systemically healthy patients, ASA class I & II
Patients willing to give an informed consent .
Patients not receiving any medication that will alter the perception of pain.
Exclusion Criteria
Allergic to DEX
Patients not willing to give an informed consent
Acute inflammation or infection at the site of surgery
Allergic rhinitis, nasal pathologies.
Pregnant and lactating women.
Bradycardia
Renal or hepatic disease
Using antipsychotic drugs, alpha blockers
Patients with a BMI of more than 27 kg/m2
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pain will be assessed preoperatively and postoperatively using VAS score. <br/ ><br>swelling and trismus. <br/ ><br>Sedation status will be assessed by a blinded observer with a modified Observer�s Assessment of Alertness/Sedation (OAA) scale --- after intranasal drug administration <br/ ><br> <br/ ><br>Timepoint: Pain will be assessed preoperatively and postoperatively using VAS score 1,6,12,24,48 hrs postoperatively. <br/ ><br>swelling and trismus assessed on 2nd and 7th postoperatively and <br/ ><br>Sedation status will be assessed by a blinded observer with a modified Observer�s Assessment of Alertness/Sedation (OAA) scale of 0 to 5 for every 10minutes to 90minutes after intranasal drug administration <br/ ><br> <br/ ><br>
- Secondary Outcome Measures
Name Time Method Parametres monitored continously <br/ ><br> Heart Rate <br/ ><br> 3-lead electrocardiogram (ECG) and <br/ ><br> SpO2 <br/ ><br>Timepoint: Parametres monitored once in every 10 mins for 90 mins <br/ ><br>Blood pressure <br/ ><br>Respiratory Rate <br/ ><br> <br/ ><br>