The Effect of Intranasal Dexmedetomidine Premedication on the Minimum Alveolar Concentration of Sevoflurane for tracheal intubation in childre
Phase 3
Completed
- Conditions
- inhalation induction of anesthesia and tracheal intubation in childrenAnaesthesiology - Anaesthetics
- Registration Number
- ACTRN12613000679785
- Lead Sponsor
- Yusheng Yao
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 90
Inclusion Criteria
American Society of Anesthesiologists physical status I-II children scheduled to undergo general anesthesia for elective minor surgery
Exclusion Criteria
Patients with airway malformation, clinical evidence of a difficult airway, any sign of upper respiratory infection, or asthma were excluded. Patients taking medication known to affect anesthetic requirements were also excluded.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method the minimum alveolar concentration of sevoflurane for tracheal intubation (MACTI); Patient’s responses to tracheal intubation were classified as ‘no movement’ or ‘movement’. ‘No movement’ was defined as the absence of purposeful movement of the extremities, movement of the vocal cords preventing intubation, and coughing or bucking during or immediately after intubation. The values of MACTI were obtained by calculating the midpoint concentration of all independent response cross-overs in which a positive response was followed by a negative response.[At the time of tracheal intubation ]
- Secondary Outcome Measures
Name Time Method included induction quality[Induction quality was briefly evaluated according to a four-point scale during the inhalation induction with sevoflurane];Incidence of adverse events(e.g.hypotention,bradycardia);<br><br>Clinically significant hypotention or bradycardia, defined as > 30% decrease in mean arterial pressure or heart rate compared with baseline. [During the study period]