Comparison of the Hemodynamic Changes of two regimens propofol + ketamin and thiopental Na + ketamin with etomidate during anesthesia inductio
Phase 2
- Conditions
- Hemodynamic Change.Postprocedural disorder of circulatory system, unspecified
- Registration Number
- IRCT201103114365N7
- Lead Sponsor
- Vice chancellor for research of Mazandaran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 120
Inclusion Criteria
Informed written consent; ASA class ?-??; Age between 18 and 45 years; Elective surgery
Exclusion criteria: Adrenal insufficiency; Received etomidate or propofol or thiopental in one week ago; Receiving steroids at 6 months ago; Sensitivity to etomidate or propofol or thiopental; Egg and soy allergy; Sepsis; endocarditis; Chronic inflammatory diseases; Any severe disease and seriously endocrine, neurological, Psychiatric and Metabolic disorders; Pregnant or lactating women; Need for rapid intubation in emergency patients; Asthma; HIV infection; History of hypertension; Taking beta blocker, calcium blockers and angiotensin II inhibitors.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Systolic blood pressure. Timepoint: 1 min after administration of hypnotic drugs just before laryngoscopy as well as 1 and 3 min after laryngoscopy and tracheal intubation. Method of measurement: Automated sphygmomanometer.;Diastolic blood pressure. Timepoint: 1 min after administration of hypnotic drugs just before laryngoscopy as well as 1 and 3 min after laryngoscopy and tracheal intubation. Method of measurement: automated sphygmomanometer.;Mean arterial pressure. Timepoint: 1 min after administration of hypnotic drugs just before laryngoscopy as well as 1 and 3 min after laryngoscopy and tracheal intubation. Method of measurement: automated sphygmomanometer.;Heart rate. Timepoint: 1 min after administration of hypnotic drugs just before laryngoscopy as well as 1 and 3 min after laryngoscopy and tracheal intubation. Method of measurement: Heart monitoring.
- Secondary Outcome Measures
Name Time Method Delirium. Timepoint: After anesthesia. Method of measurement: Inspection.;Nausea and vomiting. Timepoint: After anesthesia. Method of measurement: Inspection.;Twitching. Timepoint: After anesthetic infusion. Method of measurement: Inspection.;Pain. Timepoint: After anesthetic infusion. Method of measurement: Inspection.