A randomized controlled clinical study of Chuanhuang prescription combined with reduced glutathione regimen in the treatment of patients with 1-2 grade AKI on the basis of 2-4 stage CKD and its clinical evaluation of early diagnostic markers

Phase 1

Recruiting

• Conditions: A on C

• Registration Number: ITMCTR2000003802
• Lead Sponsor: Shanghai Municipal Hospital of Traditional Chinese Medicine

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 20 February 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

1. Patients who meet the diagnostic criteria of ckd2-4 and grade 1-2 of acute kidney injury;
2. Patients who meet the TCM syndrome diagnostic criteria of spleen and kidney deficiency and toxin and blood stasis syndrome;
3. 24h U-pro <= 2.5g;
4. Patients aged from 18 to 75 years old;
5. Patients voluntarily participate in the clinical trial and sign the informed consent.

Exclusion Criteria

1. Pregnant women or women preparing for pregnancy and lactation;
2. Patients with severe primary diseases of other organs and in urgent need of immediate treatment, or with consumptive system diseases such as malignant tumor and active tuberculosis;
3. Patients after renal transplantation;
4. Patients with mental illness and those who can't cooperate with each other;
5. Patients who are allergic to treatment drugs;
6. Patients who are participating in other drug clinical trials or have participated in other clinical trials within 3 months.

Study & Design

• Study Type: Interventional study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Blood urea nitrogen;Acr;SOD;Serum creatinine;the syndrome scores of TCM;eGFR;Blood potassium;IL-6;MDA;TNF-a;24h U-pro;