A randomized controlled clinical Trial for Qingre Huayu Formula on left ventricular remodeling in patients with ST segment elevation myocardial infarctio
- Conditions
- ST segment elevation myocardial infarction
- Registration Number
- ITMCTR2000003834
- Lead Sponsor
- Shuguang Hospital of Shanghai University of Traditional Chinese
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- Not specified
(1) patient aged 18 and 85 years old;
(2) It conforms to the diagnosis of acute myocardial infarction in Western medicine, and is diagnosed as death heartache by Traditional Chinese medicine. The syndrome belongs to the syndrome of blood stasis and obstruction;
(3) Patients with single-vessel, double-vessel or three-vessel coronary lesions diagnosed by emergency coronary angiography and and PCI with onset time less than 6 hours.
1. Patients who did not undergo coronary angiography +PCI;
2. Pregnant women and lactating women;
3. Chest pain caused by other heart diseases, severe cardiac neurosis, menopausal syndromes, hyperthyroidism, cervical spondylosis, biliary disease, stomach and esophageal reflux, etc.;
4. Patients with severe heart and lung dysfunction and severe arrhythmia;
5. Patients with multiple organs such as heart, liver, brain and kidney, as well as hematopoietic system and other serious primary diseases, malignant tumors, or mental diseases;
6. Patients who are known to be allergic to such drugs and have a severe allergic constitution;
7. Recent (within 1 month) major trauma or surgical history, etc.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method echocardiography (LVDd, LVSd, IVSd, LVpWd, LVEF, LVMI, LVRI);lymphocyte (Th1, Th2);inflammatory factor (IL-6, IL-17, IL-10, TGF-beta etc.);chemokine receptor (CXCR1-4\CCR-7 etc.);chemotactic factor (CCL1-5, 11 etc.);
- Secondary Outcome Measures
Name Time Method Blood routine examination, hypersensitive CRP, SOD, BNP, TNI.;Blood routine and stool routine;TCM symptom improvement score;Liver function (ALT, AST, TBIL, ALP, GT), renal function (BUN, Cr, urinary microalbumin), urinary routine and urinary sediment microscopic examination, creatine kinase CK;Score of TCM syndrome of Heat and Phlegm-Blood Stasis ;Adverse events and adverse reactions shall be recorded at any time;