Effect of Magnetic Stimulation in Parkinsons Disease
- Conditions
- Health Condition 1: G20- Parkinsons disease
- Registration Number
- CTRI/2019/11/021925
- Lead Sponsor
- ICMR
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
1. Diagnosis of clinically definite PD, defined by UKPD brain bank clinical and diagnostic criteria. With presence of at least 1 out of 3 cardinal motor features of PD (resting tremor, rigidity, and postural impairment like bradykinesia);
2. PD patients of both gender with H&Y stage above 1 to 2.
3. PD patients between age 45 to 75 on stable medication for at least 30 days.
1. Features suggestive of other causes of Parkinsonism/ Parkinson-plus syndromes;
2. History of ICSOL (intracranial space occupying lesion) or brain surgeries, significant headaches, epilepsy or seizure disorder, mass lesions, or major head trauma leading to loss of consciousness of any length;
3. Family (1st degree relatives) history of epilepsy;
4. Presence of contraindications for functional magnetic resonance imaging (fMRI) like metal implants, and claustrophobia;
5. History of schizophrenia, schizoaffective disorder, other psychosis, rapid-cycling bipolar illness, alcohol/drug abuse within the past year;
6. Need for rapid clinical response due to conditions such as psychosis, or suicide tendency;
7. Patients with uncontrolled hypertension and diabetes and other uncontrolled medical illness. Patients with hypertension or diabetes would be included only if they are stable on medication for last six months.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method PDRS, PDQ 39, LED,Timepoint: Day 1 and Day 6
- Secondary Outcome Measures
Name Time Method MERTimepoint: During Scheduled DBS surgery;resting fMRITimepoint: Day 1 and Day 6