Therapeutic effects of intravenous lipid emulsion in tricyclic antidepressants toxicity

Phase 2

• Conditions: Tricyclic antidepressants toxicity.; Poisoning by psychotropic drugs, not elsewhere classified/Tricyclic and tetracyclic antidepressants

• Registration Number: IRCT2012061610017N2
• Lead Sponsor: Tehran University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 108

Inclusion Criteria

all patients with TCA toxicity according to patient history by himself or other sources of history, who are over 16 and have the indication for starting bicarbonate therapy. Exclusion criteria: patients with renal failure; pulmonary edema; brain edema; toxication with carbamazepine or phenothiazine in addition to TCA.

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
ormalization time for blood pressure. Timepoint: Minutes of 30, 60, 90, 240, 480 and 720. Method of measurement: Patients’ blood pressure would be detected by mercury barometer in mmHg and the time that blood pressure reach above 90 mmHg will be noted.;Normalization time for EKG. Timepoint: Minutes of 30, 60, 90, 240, 480 and 720. Method of measurement: Checklists to be filled by the patients physician.

Secondary Outcome Measures

Name	Time	Method
Fnal mortality and morbidity. Timepoint: At the patient discharge time. Method of measurement: Observation.