Use of a Functional Neuroimaging Battery for the Evaluation of a Meditation Retreat

Completed

• Conditions: Healthy
• Interventions: Other: Meditation Retreat

• Registration Number: NCT02443766
• Lead Sponsor: Thomas Jefferson University

Brief Summary

Over 2 decades scientists have been studying the effect on brain function from meditation practices. The purpose of this study is to measure the effect of a meditation retreat program on serotonin and dopamine transporter binding and changes in cerebral blood flow. The retreat program that will be followed is a week-long retreat called the Ignatian Retreat.

Detailed Description

This study will utilize DaTscan single photon emission computed tomography (SPECT) and functional magnetic resonance imaging (fMRI) in healthy subjects within one month of entering the retreat. The study uses DaTscan to measure the effect on serotonin and dopamine transporter binding, and functional magnetic resonance imaging (fMRI) to measure the effect on cerebral blood flow. The Ignatian Retreat is a weeklong retreat which involves meditation and prayer.

Additionally, study participants will complete a variety of questionnaires and scales to measure psychological and spirituality states. The scans and questionnaires will be completed before and after the participant has completed the retreat. The ultimate goal of the study is to analyze and compare pre and post imaging and neuropsychological and spirituality changes in healthy controls who participate in this retreat.

Study Timeline

• Study Start: 2012-01-05
• Study First Submitted: 2015-02-06
• Study First Submitted QC: 2015-05-11
• Study First Posted: 2015-05-14
• Primary Completion: 2017-03-02
• Study Completion: 2017-03-02
• Status Verified: 2022-07
• Last Update Submitted: 2022-07-20
• Last Update Posted: 2022-07-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 14

Inclusion Criteria

• Able to give informed consent and willing to complete the study.
• Willing to undergo the full imaging procedures.
• Women of childbearing potential with a negative serum pregnancy test.

Exclusion Criteria

• Any neurological or psychiatric disorders, including drug or alcohol abuse, that may interfere with cerebral blood flow as determined by the principal investigator.
• Any medical conditions that may interfere with cerebral blood flow as determined by the principal investigator.
• Currently taking medication that might affect cerebral blood flow (i.e. antidepressants, antipsychotics, anxiolytics, benzodiazepines, sedatives, antiseizure medications)
• Subject is unable or unwilling to lie still in the scanner (i.e. due to claustrophobia or weight > 350 pounds)
• Subject has metal in their body or other reason that they cannot undergo magnetic resonance imaging.
• Previous brain surgery or intracranial abnormalities they may complicate interpretation of the brain scans. (e.g. stroke, tumor, vascular abnormality).
• Pregnancy
• Allergy to iodine or shellfish.
• Concurrent participation in another research protocol that might affect the outcome of this study as determined by the principle Investigator.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Healthy Subjects	Meditation Retreat	Healthy subjects will attend the weeklong meditation retreat.

Primary Outcome Measures

Name	Time	Method
Single Photon Emission Computed Tomography (SPECT) Imaging (DaTScan)	Within one month of the retreat	To detect changes in dopamine and serotonin before and after a meditation retreat program in serotonin transporter and dopamine transporter binding.

Secondary Outcome Measures

Name	Time	Method
functional MRI	Within one month of the retreat	To detect changes in cerebral blood flow before and after a meditation retreat program.

Trial Locations

Locations (1)

Thomas Jefferson University; 🇺🇸 Philadelphia, Pennsylvania, United States