The effect of nebulized dexmedetomidine on blood pressures and heart rate during start of anaesthesia

Completed

Conditions: Medical and Surgical,

Registration Number: CTRI/2019/01/017060

Lead Sponsor: Dr Satyajeet Misra

Brief Summary: Laryngoscopy and intubation cause increase in heart rate and blood pressure which may be harmful in patients with coronary artery, cerebrovascular or intracranial disease. Various drugs like opioids, beta blockers and calcium channel blockers, local anaesthetic agents and alpha-2 receptor agonists have been tried to obtund this response with varying degrees of success. Dexmedetomidine, an alpha-2 receptor agonist, when tried by the intravenous route is effective in minimizing this response but causes hypotension and bradycardia. Nebulized route will have the advantage of minimal systemic effects. Thus, it would be of value addition to study whether the inhaled route of administration of dexmedetomidine is effective in minimizing the hemodynamic effects of laryngoscopy and intubation without causing the systemic side effects of hypotension and bradycardia. Till date, no trial has ever studied the effect of nebulized dexmedetomidine on the hemodynamic response to laryngoscopy and intubation.

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 120

Inclusion Criteria

Adult patients posted for elective surgery will be recruited into the trial after obtaining their written informed consent.
The dexmedetomidine group will receive nebulization with 1 microgram/kg dexmedetomidine diluted in 3-4 ml normal saline 30 minutes before induction of anaesthesia.
Heart rate and blood pressure responses to laryngoscopy and intubation will be recorded for 10 minutes after laryngoscopy.
The normal saline group (control) will receive nebulization with normal saline (3-4 ml) 30 minutes before induction of anaesthesia and heart rate and blood pressure responses to laryngoscopy and intubation will be recorded for 10 minutes after laryngoscopy.

Exclusion Criteria

Patients who undergo emergency surgeries, have known or unanticipated difficult airway and those who are on anti-hypertensive medications will be excluded from the trial.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Changes in heart rate and blood pressure between the two groups	Upto 10 minutes following laryngoscopy

Secondary Outcome Measures

Name	Time	Method
Postoperative nausea and vomiting and sore throat	First 2 hours following surgery

Trial Locations

Locations (1): AIIMS Bhubaneswar
🇮🇳
Khordha, ORISSA, India
AIIMS Bhubaneswar
🇮🇳Khordha, ORISSA, India
Dr Satyajeet Misra
Principal investigator
9438884048
misrasatyajeet@gmail.com