Effect of perioperative ketamine on postoperative cognition – a randomized placebo-controlled trial
Recruiting
- Conditions
- postoperative cognitive decline
- Registration Number
- NL-OMON20273
- Lead Sponsor
- eiden University Medical Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 50
Inclusion Criteria
Patients planned for elective surgery lasting > 2 1 h that require postoperative pain relief will be enrolled in the study after written informed consent is obtained.
Exclusion Criteria
•age < 54 years,
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method • To assess the effect of perioperative ketamine on postoperative cognitive function on day 1 and 30 following surgery.
- Secondary Outcome Measures
Name Time Method • To assess the effect of perioperative ketamine on postoperative pain and perioperative analgesics consumption on days 1 and 2 following surgery and persistent pain as measured on day 30 following surgery.<br /><br>• To assess the effect of perioperative ketamine on depth of anesthesia and sedation (postoperatively) and nociceptive level during anesthesia.<br /><br>• To assess side effects during ketamine administration: hypertension, tachycardia, nausea/vomiting, psychomimetic side effects, lightheadedness/dizziness, drug high and elevated liver enzymes. <br /><br>• The assess the effect of ketamine on inflammatory marker C-reactive protein on day 1 after surgery.<br>