Effect of perioperative ketamine on postoperative cognition * a randomized placebo-controlled trial

Completed

• Conditions: postoperatieve cognitie; postoperative cognitive dysfunction

• Registration Number: NL-OMON44544
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2019-02-21
• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 50

Inclusion Criteria

Patients planned for elective surgery lasting > 1 h that require postoperative pain relief will be enrolled in the study after written informed consent is obtained.

Exclusion Criteria

* age < 54 years,
* body mass index > 35 kg/m2,
* history or present psychiatric disease,
* untreated/uncontrolled hypertension (with a diastolic blood pressure > 100 mmHg), epilepsy,
* increased intracranial pressure,
* untreated hypertension,
* untreated ischemic cardiac disease,
* inability to communicate in the Dutch language,
* inability to give informed consent.
* Known liver disease
* inability to wear the RespiR8 mask

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Cognition assessment accoring to the dual task test, the NeuroCart battery and<br /><br>the MiniMental State Examination.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Pain relief/chronic pain development at 30 days<br /><br><br /><br>Effect breathing frequency on cognitive function</p><br>