Apelin Levels and G212A Polymorphism of Apelin Receptor (APJ)

Completed

• Conditions: Diabetes Mellitus Type 2; Obesity; Insulin Resistance

• Registration Number: NCT01121172
• Lead Sponsor: Aristotle University Of Thessaloniki

Brief Summary

The aim of this study is to investigate serum apelin levels as well as their possible association with G212A polymorphism of the apelin receptor in obese children and adolescents.

So far apelin has been reported to be involved in the pathophysiology of various heart diseases such as cardiomyopathies and heart failure. According to recent reports in adults apelin seems to be associated with impaired glucose metabolism, particularly in newly diagnosed diabetes type 2 patients. Obesity is associated with insulin resistance and compensatory hyperinsulinemia leading to diabetes mellitus type 2 even in youngsters. The researchers will try to investigate the role of this new adipokine in order to early detect and to prevent similar entities in childhood obesity.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-05
• Study First Submitted: 2010-05-04
• Study First Submitted QC: 2010-05-11
• Study First Posted: 2010-05-12
• Primary Completion: 2012-06
• Study Completion: 2014-01
• Results First Submitted: 2016-03-15
• Status Verified: 2016-04
• Results First Submitted QC: 2016-04-13
• Last Update Submitted: 2016-04-13
• Results First Posted: 2016-05-19
• Last Update Posted: 2016-05-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 180

Inclusion Criteria

• Obese children and adolescents (aged 2-16 years old)

Exclusion Criteria

• Chronic diseases
• Hypothyroidism
• Medication

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Serum Apelin Levels	First day after enrollment and after 8-hours of night fasting, at approximately 8:00 pm in the morning	Apelin levels were measured in serum of participants, in fasting state

Secondary Outcome Measures

Name	Time	Method
Frequency of G212A Polymorphism of Apelin Receptor in Obese Children and Adolescents	First day after enrollment	Number of participants with Apelin Receptor Gene G212A polymorphism by genotype group

Trial Locations

Locations (1)

Unit of Pediatric Endocrinology, Diabetes and Metabolism-4th Department of Pediatrics, Medical School of Aristotle University of Thessaloniki; 🇬🇷 Thessaloniki, Greece