Serum Apelin Levels and G212A Polymorphism of Apelin Receptor (APJ)in Obese Children and Adolescents.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 180
- 试验地点
- 1
- 主要终点
- Serum Apelin Levels
研究概览
简要总结
The aim of this study is to investigate serum apelin levels as well as their possible association with G212A polymorphism of the apelin receptor in obese children and adolescents.
So far apelin has been reported to be involved in the pathophysiology of various heart diseases such as cardiomyopathies and heart failure. According to recent reports in adults apelin seems to be associated with impaired glucose metabolism, particularly in newly diagnosed diabetes type 2 patients. Obesity is associated with insulin resistance and compensatory hyperinsulinemia leading to diabetes mellitus type 2 even in youngsters. The researchers will try to investigate the role of this new adipokine in order to early detect and to prevent similar entities in childhood obesity.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 2 Years 至 16 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Obese children and adolescents (aged 2-16 years old)
排除标准
- •Chronic diseases
- •Hypothyroidism
- •Medication
结局指标
主要结局
Serum Apelin Levels
时间窗: First day after enrollment and after 8-hours of night fasting, at approximately 8:00 pm in the morning
Apelin levels were measured in serum of participants, in fasting state
次要结局
- Frequency of G212A Polymorphism of Apelin Receptor in Obese Children and Adolescents(First day after enrollment)
研究者
Assimina Galli-Tsinopoulou
As. Professor in Pediatric Endocrinology
Aristotle University Of Thessaloniki