Systems biology of Reelin-associated neuropsychiatric disorders

• Conditions: F00; F20.0; F32.1; F32.2; F33.1; F33.2; F31; Dementia in Alzheimer disease; Paranoid schizophrenia; Moderate depressive episode

• Registration Number: DRKS00004761
• Lead Sponsor: Abtl. Psychiatrie und Psychotherapie, Universitätsklinikum Freiburg

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2013-05-14
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

1) The ICD-10 criteria must be fulfilled for following disorders
a) Schizophrenia, paranoid type
b) Major depression
c) bipolar affective Disorder
d) Alzheimer's Disease
2) There has to be a previous episode of the diseases a), b), c)
3) The minimum age presupposed 18 years (legal age)

Exclusion Criteria

1) Axis II Disorder
2) Axis I Co- Morbidity
3) Chronical Progress
4) Maximum age presupposed 65 years for the diseases a), b), c)

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
global sequencing of all Reelin associated genes and reestablish a gene databbase with intent to detect <br>- gene polymorphism of the reelin system in psychiatric patients<br>- de novo mutaions<br>- specific mutations, which were detected by the other subprojects

Secondary Outcome Measures

Name	Time	Method
Evaluation of hippocampal declerative Memory, Amygdala associated fear conditioning, cortical synaptic excitability and the results of brain imaging