Comparison between nebulization by ketamine versus magnesium sulphate on incidence of post operative sore throat after endotracheal intubation

Not yet recruiting

• Conditions: Medical and Surgical,

• Registration Number: CTRI/2023/05/052303
• Lead Sponsor: Ramandeep Kaur

Brief Summary

Comparison of effect of preoperative nebulization with Ketamine versus Magnesium Sulphate on incidence of postoperative sore throat in patient undergoing surgery in general anaesthesia with endotracheal intubation.

Purpose of trial is to compare the incidence of sore throat at 0hours, 2hours, 6 hours, 8hours, 12hours, 24hours.

Hemodynamic parameters are compared.

Preoperative nebulization will be done for 10mins with ultrasonic/mesh nebuliser machine.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2023-03-05
• Study Start: 2023-05-20

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 210

Inclusion Criteria

ASA physical status 1-2 Supine position under General Anaesthesia Informed Consent.

Exclusion Criteria

Patients with Physical Status of ASA Grade 3 or greater Preoperative sore throat Upper airway infection Duration of surgery >120 mins Oral surgeries Pregnant women Severe cardiorespiratory, hepatic, renal, neurological or endocrinal disease Patients with known hypersenstivity or drug allergies Obese patients weight >80kg Epileptic patient Nausea, retching or vomiting within 48hr before surgery History of motion sickness Patients who refuse to participate in the study.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To evaluate and compare effect on hemodynamics of the patient after magnesium sulphate and ketamine nebulization and normal saline nebulization.	0 hour, 2 hours, 6 hours, 8 hours, 12hours, 24hours
To evaluate and compare the incidence of postoperative sore throat after magnesium sulphate and ketamine nebulization and normal saline nebulization.	0 hour, 2 hours, 6 hours, 8 hours, 12hours, 24hours

Secondary Outcome Measures

Name	Time	Method
To evaluate side effect (if any) of ketamine and magnesium sulphate.	To evaluate patients satisfaction with nebulization done by ketamine and magnesium sulphate.

Trial Locations

Locations (1)

subharti medical college and hospital; 🇮🇳 Meerut, UTTAR PRADESH, India

subharti medical college and hospital

🇮🇳Meerut, UTTAR PRADESH, India

Ramandeep Kaur

Principal investigator

8755026625

ramansr31@gmail.com