Cardiac mitochondrial function; Comparison of in and ex vivo measurements

Completed

• Conditions: diabetic cardiomyopathy; 10019280; 10012653

• Registration Number: NL-OMON47816
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 45

Inclusion Criteria

- Patients undergoing elective valve replacement or cardiopulmonal bypass surgery
- Gender: male or male
- The patients should be aged 40-75 years
- The type 2 diabetic patients should be obese (BMI > 27 kg/m2) and non-insulin dependent
- The obese controls should be BMI matched with the diabetic patients (BMI > 27 kg/m2)
- The lean subjects should have a normal BMI (20-25 kg/m2)

Exclusion Criteria

- Insulin dependent diabetic subjects.
- Patients with instable angina or heamodynamically instable patients
- Use of Thiazolidines (glitazone/rosiglitazone/pioglitazone/troglitazone)
- Weight gain/loss > 3 kg in the last 6 months or signs of cachexia
- Contraindications for MRI scans.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary goal is to compare in vivo with ex vivo measurements of<br /><br>mitochondrial function through regression analysis. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Furthermore markers of PPAR-expression will be examined and statistical<br /><br>analysis will be done to assess differences between groups<br /><br>(diabetic/lean/obese) where P<0.05 will be considered statistically significant<br /><br>different. Also liver fat accumulation will be determined with MRI in order to<br /><br>asses the relationships between liver fat accumulation and cardiac metabolism.</p><br>