An association between mitochondrial dynamic and cell death markers in peripheral blood mononuclear cell and non-alcoholic steatohepatitis with significant liver fibrosis

Completed

• Conditions: To evaluate an association between mitochondrial dynamics and cell death markers from PBMCs and the presence of NASH with significant fibrosis among patients with NASH or non-alcoholic fatty liver disease (NAFLD); Non-alcoholic fatty liver disease (NAFLD); Metabolic syndrome; Mitochondria dynamic function; Magnetic resonance imaging (MRI); MR elastography; Peripheral blood mononuclear cell (PBMC); Apoptosis; Mitophagy; Inflammatory cytokines

• Registration Number: TCTR20230824010
• Lead Sponsor: Faculty of Medicine, Chiang Mai University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2022-12-27
• Study Start: 2023-08-24
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 22

Inclusion Criteria

(i) age more than 18 years
(ii) diagnosed with metabolic
syndrome according to NCEP III criteria
(iii) schedule for bariatric surgery
(iv) history of alcohol drinking less than 10 g/day in female and 20g/day in male in the past 12 months.

Exclusion Criteria

(i) presence of other conditions that may be associated with hepatic steatosis identified by history, physical examination, and laboratory investigation
(ii) the presence of infectious or autoimmune liver disease
(iii) having renal dysfunction (estimated glomerular infiltration rate by Chronic Kidney Disease Epidemiology Collaboration method < 60 mL/min/1.72m2; (iv) pregnancy or breastfeeding and (v) patients unable to obtain informed consent.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Correlation of mitochondrial 12 months Association between mitochondrial dynamics and cell death markers from PBMCs and the presence of NASH with significant fibrosis among patients with NASH or non-alcoholic fatty liver disease (NAFLD).

Secondary Outcome Measures

Name	Time	Method
Compare the difference 12 months mitochondria dynamic function test