Effect of Perioperative Intravenous Lidocaine Infusion on Postoperative Recovery in Patients Undergoing Arthroscopic Rotator Cuff Repair Under General Anesthesia

Not Applicable

Completed

• Conditions: Rotator Cuff Tears
• Interventions: Drug: Normal saline; Drug: Lidocaine

• Registration Number: NCT04061057
• Lead Sponsor: Yonsei University

Brief Summary

Arthroscopic rotator cuff repair is a commonly performed procedure but is known to cause significant postoperative pain. Effective analgesia after rotator cuff repair is crucial in improving the well-being of the patient but also to ensure long-term rehabilitation. The most commonly used analgesic for acute postoperative pain is opioids. However, the use of opioids is accompanied by several side effects which include but are not limited to nausea/vomiting, urinary retention, itching sensation and sometimes dizziness, respiratory depression and hypotension in higher doses. As of late, many efforts are aimed toward decreasing the use of opioids by using multimodal analgesia. Among such methods, intravenous lidocaine has been reported to be effective, safe and economic in various procedures. However, the existing evidence is mostly focused on laparoscopic procedures. The present study aims to find whether perioperative infusion of lidocaine is able to decrease opioid requirements after surgery and also improve postoperative pain compared to placebo in patients undergoing arthroscopic rotator cuff repair.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-03-19
• Primary Completion: 2019-02-11
• Study Completion: 2019-02-11
• Status Verified: 2019-08
• Study First Submitted: 2019-08-12
• Study First Submitted QC: 2019-08-16
• Last Update Submitted: 2019-08-16
• Study First Posted: 2019-08-19
• Last Update Posted: 2019-08-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 98

Inclusion Criteria

1. ASA class 1-3 adults over 19 years scheduled for elective arthroscopic rotator cuff repair

Exclusion Criteria

1. Known allergies to lidocaine or propofol
2. Cardia arrhythmia
3. History of epilepsy or seizures
4. Liver/kidney failure
5. History of recent strong opioid use

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Normal saline	Normal saline	Perioperative IV normal saline infusion
IV lidocaine	Lidocaine	Perioperative IV lidocaine infusion

Primary Outcome Measures

Name	Time	Method
Fentanyl requirement using IV PCA	24hours after surgery	Dose of fentanyl infused via IV PCA machine during first 24 hours after surgery.

Trial Locations

Locations (1)

Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institue, Yonsei Universiy College of Medicine; 🇰🇷 Seoul, Korea, Republic of